![]() The treatment of OP poisoning includes decontamination, supportive care, and the antidotes, atropine and oximes. ![]() Mortality due to OP poisoning is typically a result of respiratory failure. The “intermediate syndrome” (IMS) may occur from 24 to 96 h after resolution of the cholinergic toxidrome and is characterized by respiratory paralysis, cranial neuropathy, proximal limb weakness, and hyporeflexia. Acetylcholine then accumulates within the nervous system overstimulating both the muscarinic and nicotinic receptors leading to a wide range of clinical effects: (1) salivation, lacrimation, urination, diarrhea, gastrointestinal distress, emesis (SLUDGE) bronchorrhea, bronchoconstriction, and bradycardia (muscarinic) (2) muscle fasciculations, weakness, and diaphragmatic paralysis (nicotinic) and (3) restlessness, dysarthria, tremor, altered mentation, psychosis, and seizure (central nervous system). Organophosphates phosphorylate the serine hydroxyl group of acetylcholinesterase to inactivate the enzyme. ![]() It is crucial for clinicians to understand the optimal treatment for acute OP poisonings, not only because of the widespread use of OP in agriculture but also due to the potential threat of chemical warfare with OP-containing agents. These agents were also used in a terrorist attack in the Tokyo subway in 1995 and have been implicated more recently in the assassination of Kim Jung Nam, the half-brother of Kim Jung Un. Organophosphates were first developed for warfare in Nazi Germany and have since been deployed multiple times with devastating effects: Iran-Iraq war (1980–1988) by Saddam Hussein and Syrian conflicts in 20. Use of OP-containing nerve gas is also an ongoing concern in present-day conflicts. Intentional poisonings comprise approximately 60–70% of pesticide poisonings in Malaysia, Indonesia, and Thailand 4. Seventy percent of unintentional poisonings are related to occupational exposures in Sri Lanka. The World Health Organization estimates that about 3 million poisonings (1 million unintentional and 2 million intentional) involving OP pesticides occur annually worldwide resulting in 220,000 deaths. Organophosphates account for the majority of pesticide-related unintentional or intentional poisonings in lower- and middle-income countries. Organophosphate (OP) compounds are used primarily as pesticides in agricultural settings but have also been developed into nerve agents such as sarin and VX. ![]() Based on our meta-analysis of the available RCTs, 2-PAM was not shown to improve outcomes in patients with acute OP poisoning. The risk of death (RR = 1.5, 95% CI 0.9–2.5) intubation (RR = 1.3, 95% CI 1.0–1.6) intermediate syndrome (RR = 1.6, 95% CI 1.0–2.6) complications (RR = 1.2, 95% CI 0.8–1.8) and the duration of intubation (mean difference 0.0, 95% CI − 1.6–1.6) were not significantly different between the atropine plus 2-PAM and atropine alone. We found five studies comprising 586 patients with varying risks of bias. Data were abstracted and risk ratios (RR) were calculated for mortality, rate of intubation, duration of intubation, intermediate syndrome, and complications such as hospital-acquired infections, dysrhythmias, and pulmonary edema. The Cochrane review handbook was used to assess the risk of bias. We searched PubMed, EMBASE, and SCOPUS up to March 2017. We performed a systematic review and meta-analysis of available randomized controlled trials (RCT) to compare 2-PAM plus atropine in comparison to atropine alone for acute OP poisoning. The benefit of adding 2-pyridine aldoxime methyl chloride (2-PAM), however, is controversial. The therapeutic role of atropine is well-established for patients with acute OP poisoning. Organophosphates (OP) account for the majority of pesticide-related unintentional or intentional poisonings in lower- and middle-income countries.
0 Comments
![]() ![]() Are you lazy like garfield? Take shortcuts to overtake the other racers with the spring! Race your friends in local or online modes, with up to eight players on 16 iconic circuits from the world of garfield. Use crazy bonus objects, like the pillow or the magic wand, to gain an edge and get over the finishing line first. If you’re interested please consider chipping in or sharing this in relevant communities.Garfield, the famous lasagna-loving Cat is back to take on Jon, odie and company in a no-holds-barred racing game! Choose your character and Kart according to their characteristics and your driving style, get off the starting line first and control skids to outrun your opponents. If this seems unrealistic, consider that the only reason MK:DD can be played online on a Wii at all is that last year, a bunch of cool people gathered $460 on a bounty that added LAN emulation to Nintendont, the homebrew app used to play GameCube games on Wii. Youll have to time this one perfectly to get a boost. SirLolz from the GameCube Online Discord has started a bounty to motivate developers to improve the game’s LAN code and let all online games be played like on that second video. updated Like in previous Mario Kart games, you can get a helpful speed boost at the starting line in Mario Kart 8. So, what can we do about this? Well, we can throw money at the problem. On the other hand, here’s an 8-player online match where the hosts live nearby: Here’s a three-player online match between people in three different This means that the quality of the gameplay varies a LOT depending on how far away the players are. Problem is, the game wasn’t really made for long distances – it was made for playing with your buddies in your dorm room while blasting Linkin Park. (provided you have all the necessary ingredients). World of Tanks Blitz, Ninjala, Luigi’s Mansion 3 DLC, Super Mario Maker 2, and various Wiimmfi games on Wii and DS.Īnyway, see our Guest Stars playlist here: and if you’d like to end up in it one day, join our Discord here: Īs we have demonstrated in this very blog before, Mario Kart Double Dash can be played online today from a real GameCube or Wii console thanks to a LAN-tunneling program called Contents 1 Gamemodes 2 Characters 2.1 Small 2.2 Medium 2.3 Large 2.4 Tricky (New) 2.5 Any 2.6 Skins 2.7 Roblox Style 2.8 Minions 2.9 Other 2.10 Pretty Cure 3 Karts/Bikes 4 Items 4.1 Returning 4. The games we personally are looking to play for future videos include Based more specifically on The Garfield Show than the fat cat’s newspaper or other incarnations, Garfield Kart features a cast of eight characters, including Garfield, Odie, Jon, Nermal. Mario Kart - Fallen Leaf Racing (MKFLR for short) is the first game is the Mario Kart: Fallen Leaf (series). There are currently 300 people in the server, and many of them are willing to play with others too. Part of a NintendoDuo video, the best way to do it would be to join our Discord and let us know! We can’t promise that we’ll play every game On, we were posting more and more videos with “guest stars.” We got so You might even have noticed that as this year went ![]() As time went on, we realized that it wasĪctually a perfect way to set up gaming sessions with our viewers and Garfield, the famous lasagna-loving cat is back to take on Jon, Odie and company in a. Two years ago, we started a Discord server without really knowing ![]() For example, many banking websites will block connections from VPN servers. ![]() Split tunneling is very useful because there are some app, programs, and websites that are simply not compatible with VPNs. Private Internet Access has added a split tunneling features. Overall, PIA does well in terms of security and privacy features, even if the ad blocker is not very robust. We compare and contrast the two in our Surfshark vs PIA guide. In terms of VPN ad blockers, NordVPN, Surfshark, and Perfect Privacy performed better than PIA, while PureVPN and CyberGhost performed the worst. ![]() When I tested different VPN ad blockers, I found that PIA’s ad blocker did not block as many domains as other options. While some ad blocker is better than no ad blocker, I would not recommend using PIA MAC as your primary ad blocker. Nonetheless, the WireGuard VPN protocol does still offer some advantages, including upgraded security and more reliability on mobile devices.īelow you can see the encryption options in the PIA Windows app: However, in our tests for this PIA review, WireGuard speeds were not very good (we’ll examine slow speeds further below). A VPN ad blocking feature called PIA MACEįirst, the WireGuard protocol is an excellent feature that usually offers big advantages with performance.Various data encryption options, including WireGuard.In addition to the multi-level kill switch we discussed above, PIA also provides: Extra privacy and security featuresĭespite being a basic VPN service, Private Internet Access still offers some good privacy and security features. In testing out the kill switch with various interruptions, everything appeared to work well. Always: Also blocks all traffic when the VPN is off.Auto: blocks outside traffic when the VPN is on.This ensures all traffic remains encrypted and protected by the VPN tunnel. PIA also implements a good kill switch with their VPN apps, which will block traffic if the VPN connection drops for any reason. Although I’m not sure I would consider PIA to be one of the best VPNs for Mac, it may still be a decent choice for Mac users. I also tested the PIA Mac OS client and found it to be secure and without leaks. You can see in our test results below that we did not identify any leaks or problems with the PIA VPN apps. So to test this, I ran both the Windows and Mac OS clients through some basic VPN tests and checks to identify leaks or broken features.īelow I’m testing the PIA Windows VPN client for leaks while connected to a server in Sweden. And while data leaks are common with some free VPN apps, this is not something we should expect with a premium (paid) service that promises security. Most people using VPNs today need a service that is secure and free of data leaks. It may be a decent choice if you want a user-friendly VPN for PC operating systems. Overall the PIA desktop clients work well. Connect on launch settings (to a specified VPN server).Settings to open VPN client on system startup.In addition to all the features we covered above, the Private Internet Access desktop client also has: The PIA VPN app hovers above the tray in the bottom-right corner of the desktop. ![]() A marketing executive at B&G Foods wanted a way to add herbs and spices without all the salt. Dash’s products were designed to fill a niche. ![]() ![]() Onion, Spices (Black Pepper, Basil, Oregano, Celery Seed, Bay, Savoury, Thyme, Cayenne Pepper, Coriander, Cumin, Mustard, Rosemary, Marjoram), Garlic, Lemon Juice Powder, Carrot, Citric Acid, Lemon Peel, Natural Lemon Flavour, Oil of Lemon, Turmeric Color, Chili Pepper. Each spice is hand-picked for a full bodied taste that will heighten the flavour of your food. (Find Out Now) Written by Kimberly Burton in Gluten Free, Pantry As part of a low-sodium diet, Mrs. Order Mrs Dash by clicking the Add to Basket button! Dash Salt-Free Garlic & Herb Seasoning Blend - compare prices, see product info & reviews, add to shopping list, or find in store. Dash Sweet Teriyaki Marinade, 12 Oz (Pack of 6) by Mrs. Eating healthy meals doesn’t mean skipping out on taste. MRS DASH ORIGINAL SEASONING BLEND SALT FREE 1 x 191g LARGER JAR AMERICAN IMPORTED. ✓ Kosher certified ✓ Sodium free ✓ Fat free ✓ Carb free INGREDIENTS Onion, Spices (Black Pepper, Basil, Oregano, Celery Seed, Bay, Savoury, Thyme, Cayenne Pepper, Coriander, Cumin, Mustard, Rosemary, Marjoram), Garlic, Lemon Juice Powder, Carrot, Citric Acid, Lemon Peel, Natural Lemon Flavour, Oil of Lemon, Turmeric Color, Chili Pepper. The flavor of this garlic and herb salt free seasoning blend is created by mixing over 20 different spices together, including black and cayenne peppers. It also elevates the taste of sauces, vinaigrettes, and even popcorn-truly a versatile spice blend. Each jar contains mixed spice allowing your palate to enjoy the flavour without the salt-ideal for sprinkling on salmon before baking or chicken before grilling. Dash is an American brand of salt-free seasoning that was introduced in 1983 and was marketed by B&G Foods. VERSATILE CONDIMENT - Order this pantry staple today Comes in 1 x 71g jar of meat seasoning.ĪLL-IN-ONE HERBS, SPICES & SEASONINGS MINUS THE SALT Bring ordinary dishes to life with the citrusy flavour of Dash Lemon Pepper Seasoning Blend.KOSHER CERTIFIED MIXED HERBS - Perfect blend of tangy lemon taste combined with the heat of pepper.Browse our wide selection of Seasonings & Blends for Delivery or Drive Up & Go. IDEAL FOR SALAD DRESSINGS - Adds a nice hint of lemon zest in salads and vinaigrettes. Dash Seasoning Blend Salt-Free Lemon Pepper - 2.5 Oz from Randalls.ALL PURPOSE SEASONING - Packed with flavourful herbs and spices, you can use it to season anything.Browse our wide selection of Seasonings & Blends for Delivery or Drive Up. MRS DASH LEMON PEPPER SPICE - Salt-free seasoning to enhance the taste of meat, poultry, or fish. Dash Seasoning Blend Salt-Free Lemon Pepper - 2.5 Oz from Jewel-Osco. ![]() What you need is a distribution certificate, not a development one, and a provisioning profile linked to that certificate with your registered devices. You are now prompted for your certificate and iOS Ad Hoc profiles. You can leave Include manifest for over-the-air installation unchecked as I'll give you the file to use. Select Ad Hoc and hit next a couple of times. Then open the Organizer (Xcode will likely open it automatically after the archive is ready) and click on Distribute Make sure you have a device selected, or Generic iOS device, as your target otherwise Archive will be disabled. The first step is creating an archive, it is exactly the same one you'd use to submit an app to the store. Let's start with the easy way: generating an IPA in Xcode. You can either generate the IPA on Xcode or via command line, and that's what my article is all about. That means you create an IPA (basically a zip containing your signed app) you can distribute over-the-air to register devices. ![]() You need to create a provisioning profile for testing so you can connect them to Xcode and install the app to debug, or you can distribute the app Ad Hoc. I usually send this link: and I eventually get the UUID I'm asking for, but I think you should rely on TestFlight if you are dealing with non tech-savvy people.Īnyway, let's suppose you have some devices registered on your developer portal. I have to say it isn't straightforward to get the UUID from your test devices if you need to ask them to a client, and that's the main advantage of using TestFlight. The former allows you to submit a build to App Store connect and immediately push it to your internal team, up to 25 members, or ask for a review and have up to 10,000 tester receive the build via the Test Flight app on their devices.īut what if you don't want to bother with creating a new app in App Store Connect? Maybe you're in the early stage of development, or just prototyping an idea of an app, or don't yet have access to Connect with your account (that shouldn't be true starting February 2019 as Apple is allowing the same account on the developer portal and Connect).Īd Hoc distribution is an easy and quick way to send an app to test devices you have register on the developer portal. There are two ways to distribute a test version of your app for iOS: TestFlight and Ad Hoc. I want to share my experience building and distributing apps with xcodebuild hoping to help some iOS developer struggling with automating build and distribution via command line. ![]() The Arts Council is also accepting individual donations to Re-create. Several Paint It! artists have already generously agreed to donate 100% of their sales to help the relief effort. They will be extending their current exhibit, Paint It! Ellicott City 2016, until the end of September with a portion of the proceeds from the sale of this work donated to the fund. The Howard County Arts Council is establishing Re-create: Ellicott City Artist Relief Fund to aid to the many artists with studios and galleries in Ellicott City who suffered substantial losses of artwork and studio space. Volunteer Opportunitiesįind more information online at. Preservation Maryland has set up an emergency flood recovery fund to aid in the repair and restoration of the City’s historic Main Street community and storefronts. The Ellicott City Partnership is currently accepting financial donations that will be used to assist merchants and residents with flood recovery. Updates to this post will be made when available. The town is not yet ready for physical volunteers, but donations, moral support and positive thoughts can be used immediately. If you're looking for a way to help, please read through the list below. The businesses and residents affected by the flooding on July 30 will need all the help they can get and many organizations and businesses are already offering an incredible amount of support at this time. ![]() Many generations of entrepreneurs have called Main Street home and the hope of many is that the tradition will continue. Old Ellicott City has a long history of strength, growth and resilience. ![]() It starts off wet but dries to a smooth satin finish, without drying out too quickly. The concealer is thin, creamy and easy to apply. However, after trying it out again today, I found myself reaching for a damp Beautyblender as the concealer was extremely streaky-but nothing a BB can’t correct. It was hygienic in the sense that I didn’t have to use my hands to hold the applicator. “Before the reign of the Beautyblender, I just used the fluffy applicator head that came with the concealer. It covered my baby dark circles well and was easy on the wallet.” This Maybelline concealer was my holy grail back when I was a teenager who could only afford drugstore brands. I look for medium to high coverage that does not oxidise to a darker shade by the end of the day. IMO I have a bad case of (uneven) dark circles, with the one under the right eye darker than the one on the left. That is why I only use concealers to hide my eye bags, breakouts, or any redness around my nose. “Concealers are a staple for me as I don’t like the tacky feeling of foundation applied on my entire face for the whole day. Chiara wears the shade 140 Honey Previous concealer experience Read on to find out how the concealer fared. Reviewers had to snap selfies and record their findings at 9am, 1pm and 9pm. To find out if it has stood the test of time, members of the Zula and Eatbook teams were tasked to pick a shade that suits their skin tone, and wear it for the entire day while working from home. But many other just-as-legit concealers with equally bold claims have been released since it was launched in 2010. Whether you’re a beauty junkie or simply spend a lot of time on YouTube, there’s a high chance you’ve heard of the Maybelline Instant Age Rewind Concealer.Ī lot has been said and written about this concealer, which claims to “fake 8 hours of sleep in under a minute and get rid of dark circles“. Zula Team Tries: Maybelline Instant Age Rewind Concealer ![]() A countersink is a shallow conical depression - usually just deep enough to make the top of the screw head flush with the surface. It can be used for decorative finishes - hiding the screw head with a dowel - or to join two pieces of material without needing a full-length screw. A counterbore is a deeper hole, wide enough to take the screw head. Is a counterbore the same as a countersink? A. Although it's not always practical, you generally get more consistent, chatter-free results using a drill press rather than a hand-held drill. It can be caused by a blunt bit or inconsistent drilling pressure. It's coarse vibration and an irregular shape, created when the countersink bit doesn't cut smoothly. The exception is precision-engineered cobalt countersinks, which can exceed $100 - though these will probably last a lifetime. From there on up, price largely depends on the quantity and quality of the drill bits, though even metal-cutting tools rarely top $40. Price You won't pay very much for good quality countersink drill bit sets, with prices starting at around $10. Countersinks specifically made for metal might have tungsten and molybdenum or cobalt added to the steel, making them very hard indeed. They can have either nickel, black oxide, or titanium nitride (TiN) coatings, which help reduce heat build-up - so they cut better and stay sharp longer - and also resist corrosion. Features All countersink bits are made of high speed steel (HSS), though finishes and additives vary. ![]() Hexagonal shanks work perfectly well in these chucks, but they are primary intended for slot in, quick-release systems - where loosening and tightening a chuck isn't necessary. Round shanks are designed primarily for inserting in a chuck - either a pillar drill, or a hand-held model. Shanks Shanks are either round or hexagonal. Guide bits aren't usually suitable for drilling metal, so countersinking holes becomes a separate process which the conical cutter is better suited for. This versatility has made it by far the more common choice in a countersink drill bit set, though conical versions remain popular with engineers and metalworkers. A variation on the guide bit uses a tapered drill, which helps center the countersink in pre-existing holes, and provides faster cutting. It can also be adjusted for different depths. It can be used to guide the countersink, or it can drill and countersink or counterbore at the same time. This has a standard drill bit with a countersink bit that fits around the shank. ![]() All-in-one The composite (or all-in-one) countersink are generally easier to line up for precise cuts. They are also very effective for deburring holes in metal and plastic (many engineers will just give them a quick twist by hand) but they are awkward to line up properly. Basic conical countersinks are used when the screw hole has already been drilled. More flutes means more cutting edges, usually resulting in a cleaner finish and faster waste clearance. ![]() Standard The basic model is a conical (or standard) cutter, usually with three to five flutes. Considerations when choosing countersink drill bit sets Countersink drill types There are two basic types of countersink drill: standard and all-in-one. We've also made a few recommendations, including our favorite, the DeWalt Countersink Drill Bit Set, which combines the clever design that the brand is known for with the fast, accurate cutting that professionals demand. To help you choose the right one, we've put together a concise guide. With the wide range of screws, a countersink drill bit set with a selection of sizes is an economical solution. When you're using screws as a fixing, neatness usually demands you use a countersink to seat the heads properly. ![]() Quick tip: These highlights are often in the background, but you can also place them in the foreground for bokeh in front of your subject. Just remember to expose for your subject and not those highlights otherwise, the subject could be thrown into silhouette. For example, if you’re photographing someone in green light, you could include bokeh balls in a complementary magenta. Using bokeh is a great excuse to pull out all the stops and get creative, so swap out your plain seamless and mix it up with textures and colors. You can also set up fairy lights, use reflective surfaces (e.g., crinkled aluminum foil), raindrops, or water droplets for an ethereal effect. Exhibit Locations:Kandy Gallery Yorkdale and Kandy Gallery at Hotel X Toronto. ![]() Look for multiple points of light for more impact, and be aware of the lighting situation wherever you plan to photograph. The first place winners for each of the six categories of this competition will have their work printed & mounted by Pikto for an exhibit in two of Neil Dankoff’s galleries, giving you exposure on a global level. You can use natural backlight filtering in through the trees outdoors or city street lights at night. “I have a bunch of favourites, but right now I like the look at the collection of fruits and veggies.Your bokeh will usually be more visible in the highlights, so plan your background accordingly. “There’s a ton of really neat areas of the discovery map but this is by far my favourite: The Big Red Eye.” – Lucas Luxton Whether you are a professional photographer or just love taking pictures of your friends and family, we want to see how you capture the bokeh effect with your camera For this photo contest, we invited you to show us how light shines through your environment to create stunning and captivating images with chances to win a Polaroid Snap Touch. In this tutorial, Ursula reveals how she shot and processed Seedling so you too can recreate this eye-catching effect, as seen in the image below. “Loving the red and burgundy colours here (must be the first day of fall)” – Adriana Formusa “Reminds me of the big Red Spot on Jupiter.” – Andy Yang “The line between humans and animals.” – Jeff Shin “Love how this image of a woman is in the middle of all these pattern photos showing the power of pattern recognition.” – Nuno Silva “This particularly colorful and floral area!” – Alexandra Kim “This is the closest thing to being surrounded by a pile of puppies you can get without having a pile of puppies.” – Nicole Hoye “The border between woods and mountains… Amazing textures…” – Alessandro Dallafina From portraits to landscapes, we’re curious to see how and what you shoot during Golden Hour, also known as magic hour. You’re done To track all entries, click here. Plus, exploring the photos in your search results is easy with navigation by clicking and dragging the visual map and zooming in and out using the + or – keys on your keyboard.īelow are some of the 500px team’s favorite spots on the map-check ’em out: Upload the image to your 500px profile, or pick an existing photo. Go ahead-try searching for any subject, from landscapes to portraits:Īs you start searching, the URL changes with every search result: With our responsive map design and presentation, searching for photos is now made easy on the eyes. How To Create A Magical Holiday Bokeh Photo Tutorials How To Create Beautiful Bokeh Images Tutorials Weekly Contest: 30 Cool Close-Up Photos + New Theme. With unique and authentic photographs from more than 70,000 photographers, our catalog is unlike any other you’ll find. ![]() So we collected our top 100,000 photos and put them together in a visual map for you to view them all at once. Our editors are always on the lookout for jaw dropping content for you to discover and stay inspired. We believe that searching for photos should be an inspiring experience. What’s the difference between 100ASA, 500px, Bokeh, and EyeEm Compare 100ASA vs. Download the 500px app for Android and iOS today Editors’ Choice Photo by Marta Bevacqua The best of the best. Searching for the top photographs on 500px Prime just got easier with our Visual Search!Īt 500px, we want you to discover and find beautiful photos with your eyes, not your keyboard. ![]() ![]() Windows 7 Download periodically updates pricing and software information of AnyMP4 Video Converter full version from the publisher,īut some information may be out-of-date. However, windows7download reserves the right to remove or refuse to post any submission for any reason. You acknowledge that you, not windows7download, are responsible for the contents of your submission. Get your hands on this robust tool today and take your video editing skills to the next level!Īll AnyMP4 Video Converter reviews, submitted ratings and written comments become the sole property of Windows 7 download. Overall, AnyMP4 Video Converter is the perfect tool for video enthusiasts who want an easy-to-use software that provides both basic and advanced video conversion and editing features. What's more, it comes with free customer support that is available 24/7. The interface is user-friendly and intuitive, making it easy for you to navigate through the tool without any hassle. This means that AnyMP4 Video Converter can convert multiple videos at once - a handy feature if you're dealing with lots of video files. The program also boasts of high-speed conversion and batch conversion to save your time. Moreover, it features an array of editing tools that allows you to trim, crop, and add watermark to your videos with ease. It also allows you to convert videos to virtually any device including smartphones, tablets, gaming consoles, and more. This software is compatible with most of the popular video formats, including MP4, MPEG, AVI, WMV, MOV, and more. Developed by AnyMP4 Studio, this software provides an array of features that caters to both beginners and professionals alike. AnyMP4 Video Converter is a versatile software tool you don't want to miss if you are looking for a comprehensive solution to your video editing and converting needs for Windows 7. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |